NFL Week 5: Betting Odds, Point Spreads, Moneylines & Totals For Every Game

Kansas City Chiefs quarterback Patrick Mahomes (15) celebrates a touchdown during an NFL football game against the Tampa Bay Buccaneers, Sunday, October 2, 2022 in Tampa, FL. The Chiefs defeat the Buccaneers 41-31. (Peter Joneleit via AP)

And then there was one – undefeated team, that is. The Philadelphia Eagles (4-0) stand alone after four weeks of NFL action. But the Arizona Cardinals await them in Week 5 in what could be a trap game if Philadelphia isn’t careful.

Other marquee matchups include the Dallas Cowboys  – winners of three straight – taking on the Los Angeles Rams, and the Cincinnati Bengals and Baltimore Ravens renewing their AFC North rivalry.

3DownNation breaks down all the odds and key information to keep an eye out for.

Week 5 NFL Odds

Indianapolis Colts vs. Denver Broncos

Underachievers will be aplenty in the NFL’s opening matchup of the week as the Broncos and Colts square off.

Russell Wilson’s start in Denver hasn’t exactly wowed fans thus far, with Week 4 being another example. The Broncos dropped a 32-23 decision to the previously winless Las Vegas Raiders. Worse yet, running back Javonte Williams (ACL) is out the rest of the year.

Meanwhile, Indy – originally given favourable odds at season’s start by sportsbooks – have sputtered to a 1-2-1 start and has its own running back issues (Jonathan Taylor will not play).

For now, oddsmakers are setting Denver as favourites.

New York Giants vs. Green Bay Packers

Quarterback injuries highlight the Giants – Packers matchup. NFL insiders report there’s “some optimism” Giants’ starter Daniel Jones (ankle) could suit up. Thus, lines could shift as Sunday approaches.

If he can’t go, things will get interesting as backup, Tyrod Taylor (concussion), is also out.

Green Bay, meanwhile, has won three straight and appears to be in the driver’s seat.

They’re favourites playing in London.

Detroit Lions vs. New England Patriots

Short-handed, both the Lions and Patriots battled tough in Week 4. However, ultimately neither came away with anything more than moral victories.

Turning the page to Week 5, this matchup sees the NFL’s highest-scoring club, Detroit (35 PTS/G), squaring off against one sputtering behind centre as both of New England’s quarterbacks – Mac Jones (ankle) and Brian Hoyer (concussion) – remain questionable.

Detroit is a favourite but injury updates could be potentially shift the odds as the week progresses.

Los Angeles Chargers vs. Cleveland Browns

Despite the absence of Myles Garrett (shoulder, bicep) and Jadeveon Clowney (ankle), the Browns’ defense was serviceable in Week 4 by limiting the Falcons to just 131 passing yards.

Unfortunately, the offense couldn’t keep pace with a number of missed red-zone opportunities.

Cleveland coach Kevin Stefanski commented he won’t know his defensive duo’s status until later in the week

Consequently, the Chargers are favourites.

Houston Texans vs. Jacksonville Jaguars

Jacksonville has now strung together three straight solid efforts and that has sportsbooks convinced for Week 5. The Jags are favourites playing at home against Houston.

In fact, Jacksonville – leading up 14 early on – was only a late-game drive away from forcing overtime with the undefeated Eagles in Week 4.

Houston – while still battling tough – will likely remain an underdog the rest of the way.

Atlanta Falcons vs. Tampa Bay Buccaneers

The Falcons have exceeded expectations thus far but they will be tested in Week 5 playing on the road versus the Buccaneers. That rings especially true considering running back Cordarrelle Patterson is out for at least the next four games (knee) as he went down in Week 4.

Tampa Bay hasn’t looked like Super Bowl contenders yet but oddsmaker are still giving the veteran squad the nod as an favourite.

Pittsburgh Steelers vs. Buffalo Bills

The Bills bounced back from their first loss of the season in Week 4. Thanks to a 21-yard field goal from Tyler Bass as time expired, Buffalo overcame a 17-point deficit en route to a 23-20 win over the Baltimore Ravens on the road.

With the gutsy win in the rearview, the Bills sit in Week 5 as whopping favourites against the Pittsburgh Steelers.

Steelers’ head coach Mike Tomlin, meanwhile, turned to a rookie QB (Kenny Pickett) in Week 4 and will lean on him again in Week 5.

Miami Dolphins vs. New York Jets

The Miami Dolphins suffered their first loss of the season in Week 4. However, that quickly became a footnote as quarterback Tua Tagovailoa suffered a traumatic brain injury that forced him to be stretchered off the field.

Tagovailoa remains in concussion protocol and is out indefinitely.

Teddy Bridgewater takes his spot and Miami – once the surprise story of the NFL – now enters Week 5 as only a favourite to the New York Jets.

Chicago Bears vs. Minnesota Vikings

Make it three weeks in the row the Chicago Bears haven’t thrown for a touchdown pass. However you want to slice, that will be difficult to overcome. Chicago – which dropped a 20-12 decision to the Giants in Week 4 – continues to boast the NFL’s worst passing game.

Meanwhile, Minnesota – coming off a 28-25 win over the Saints in London – has won two straight.

The Vikings are favourites.

Tennessee Titans vs. Washington Commanders

As favourites, the Tennessee Titans hold one of the tightest spread of the week against the Washington Commanders.

That may come as somewhat of a surprise to some bettors. After all, Washington has dropped three straight games, including a rough 25-10 loss to the Cowboys in Week 4. Commanders QB Carson Wentz threw for just 170 yards and two picks in the matchup.

To that end, Tennessee has recorded 10 sacks over its past four matches – a formula that has oddsmakers slightly favouring the road team.

Seattle Seahawks vs. New Orleans Saints

Seattle Seahawks quarterback Geno Smith continues to exceed expectations as his club took down the Detroit Lions 48 – 45 in Week 4. Smith went for 300-plus yards for the second consecutive week while adding a pair of touchdowns.

Meanwhile, New Orleans is coming back from London so travel fatigue could be a consideration. Injuries as well – Jameis Winston, Alvin Kamara, Michael Thomas – for that matter.

Nevertheless, oddsmakers are favouring the Saints () at the Superdome.

San Francisco 49ers vs. Carolina Panthers

Two of the lesser throwing quarterbacks in the league have oddsmakers setting the lowest over/under (39.5) of the week for the 49ers – Panthers matchup.

Granted, San Fran QB Jimmy Garoppolo had his best outing of the year in Week 4 going 16-of-27 for 239 yards and one touchdown.

On the other hand, Carolina’s Baker Mayfield (22-of-36, 197 yards) had nine passes batted while throwing two picks in a rough 26-16 loss to the Cardinals.

Unsurprisingly, San Francisco is a favourite.

Philadelphia Eagles vs. Arizona Cardinals

The Philadelphia Eagles keep on finding ways to win games. Week 4 was no different as the club rallied from a 14-point deficit to take down the Jaguars 29-21.

Philadelphia’s defense was critical, creating five turnovers while the offense went for 401 total yards including 29 unanswered points.

Indeed, Arizona had one of its better performances of the year against Carolina in Week 4.

But the Eagles remain the sizable favourites playing on the road.

Dallas Cowboys vs. Los Angeles Rams

Cooper Rush became the first Cowboys quarterback to win the first four starts of his career in Week 4. Multiple reports indicate Dak Prescott (thumb) is “aiming” for a Week 5 return against the Los Angeles Rams.

Originally, Los Angeles opened as a -6 home favourite. But that line has since dwindled to .

Cincinnati Bengals vs. Baltimore Ravens

Lost in the aftermath of Dolphins quarterback Tagovailoa’s head injury was the fact that Cincy put together its second straight win in Week 4.

Now a showdown with the Ravens – smarting from a blown 17-point second-half lead against the Bills – awaits them in Week 5.

Baltimore has looked better of late with running back J.K. Dobbins (two touchdowns in Week 4) continuing to round into form.

To that end, Baltimore is a favourites despite Cincy having extended rest.

Las Vegas Raiders vs. Kansas City Chiefs

After picking up its first win of the season, things won’t get much easier for the Raiders in Week 5. They head into the MNF’s primetime matchup as underdogs against the Kansas City Chiefs.

Perhaps that is with good reason as the Chiefs shredded the Buccaneers’ stingy defense in Week 4 for an impressive 41-31 victory. Previously, Tampa hadn’t conceded more than 14 points.

Oddsmakers are expecting a similar shootout to the week prior as the over/under sits at – the highest of Week 5.

Jose Colorado is a British Columbia-based writer. He lives in Burnaby and loves sports, anime, writing, business, and the occasional walk on the beach.