NFL Week 4 Betting: Odds, Spreads, Moneylines & Totals For Each Game

Wide receiver (10) Cooper Kupp of the Los Angeles Rams runs the ball for a touchdown against the Arizona Cardinals in an NFL football game, Sunday, Sept. 25, 2022, in Glendale, AZ. Rams won 20-12. (AP Photo/Jeff Lewis)

The Miami Dolphins and Philadelphia Eagles stand alone entering Week 4. They are the two lone undefeated clubs following a thrilling set of games in Week 3 that surprised — and even maybe fooled — many sports bettors.

Upsets were aplenty, but the next wave of matchups is already fast approaching with a Super Bowl LV rematch between the Kansas City Chiefs and Tampa Bay Buccaneers headlining the action.

3DownNation breaks down all the NFL Week 4 betting lines.

Week 4 NFL Odds

Miami Dolphins vs. Cincinnati Bengals

The Miami Dolphins are officially the talk of the NFL world after taking down the Super Bowl favourite Buffalo Bills 21-19 in Week 3.

But a quick turn-around date for Thursday night may do them in as the club is dealing with multiple injuries across the board. The biggest one: QB Tua Tagovailoa (ankle, back). He is expected to play Thursday.

Meanwhile, Cincy — fresh off its first win of the year — seems to be in the driver’s seat playing at home. The Bengals are favourites.

Minnesota Vikings vs. New Orleans Saints

The Minnesota Vikings () and the New Orleans Saints kick off the 2022 International Series as the pair square off in London, U.K., this Sunday.

Thus, home-field advantage will be of little concern. Fatigue and injuries, however, will.

To that end, New Orleans finished its 22-14 Week 3 loss to the Carolina Panthers without four of its top five receivers.

Add in an ailing quarterback in Jameis Winston (transverse back fracture) and it’s easy to see why oddsmakers are favouring Minnesota.

Seattle Seahawks vs. Detroit Lions

Through three weeks, Detroit continues to battle tough with its two losses coming from a combined seven points.

Safety Tracy Walker (Achilles) is done for the year and running back D’Andre Swift (ankle, shoulder) will likely be sidelined for Week 4.

Regardless, due to the Lions’ high-powered offence and its recent performances, sportsbooks are giving them the nod at over the Seahawks in Week 4.

New York Jets vs. Pittsburgh Steelers

The stage is set for Zach Wilson’s (knee) return in Week 4. But sportsbooks aren’t convinced it will be enough for the Jets as the Pittsburgh Steelers are favourites playing at home.

Neither team looked impressive in Week 3 with both suffering double-digit losses.

To that end, expect a defensive slugfest. The over/under is set at .

Chicago Bears vs. New York Giants

Abysmal, woeful or awful. However, you want to define it – that is what Chicago’s passing game has been thus far this season.

Consider the Bears are the only NFL team to average less than 100 passing yards per game (78.3). The next closest is Carolina at 161.3.

That is simply too much for oddsmakers to overlook. New York – playing at home – is a favourite.

Tennessee Titans vs. Indianapolis Colts

The Colts gutted out their first win of the season in a surprising 20-17 victory over Kansas City in Week 3. Some of that can be attributed to the return of wideouts, Michael Pittman (72 yards) and Alec Pierce (61), who both returned to the lineup.

Despite Tennessee having Indianapolis’ number of late, winning its past three encounters, the Colts have a slight edge at the books as favourites.

Los Angeles Chargers vs. Houston Texans

Things went from bad to worse for the Los Angeles Chargers in Week 3 as they got rocked 38-10 at home to the Jacksonville Jaguars. To add insult to injury, Pro Bowl left tackle Rashawn Slater (ruptured bicep) was injured in the game and is expected to miss the rest of the season.

Thankfully – for Los Angeles fans – Keenan Allen (hamstring) is practicing again. Sportsbooks have Los Angeles as a favourite currently.

Cleveland Browns vs. Atlanta Falcons

The Cleveland Browns are favourites playing on the road against the Atlanta Falcons, but that could move before Sunday.

That’s largely because Browns’ defensive end Myles Garrett was involved in a horrific car crash on Monday – putting his status in question.

If he’s unable to play Sunday, the Browns’ defense may have their hands full; Atlanta averages 26.7 points per game– ninth-best in the NFL.

Washington Commanders vs. Dallas Cowboys

Dallas Cowboys star quarterback Dak Prescott is reportedly considering a Week 4 return versus the Commanders.

How that will impact the odds, however, remains to be seen. Consider Dallas is 2-0 with backup Cooper Rush at the helm this season including its latest 23-16 win in Week 3 against the New York Giants on primetime MNF.

Either way, Prescott’s status is sure to shift the odds.

Currently, the Cowboys stand as favourites playing at home.

Jacksonville Jaguars vs. Philadelphia Eagles

The Philadelphia Eagles did nothing but improve their odds to sportsbooks in Week 3 as they dominated the Commanders 24-8, recording nine sacks and allowing only 240 total yards.

On the other hand, Jacksonville is coming off its most impressive win in recent memory via a 38-10 thrashing of the Chargers.

Nonetheless, oddsmakers clearly need to see more from the Jags. Philadelphia is a favourite at home.

Buffalo Bills vs. Baltimore Ravens

A nail-biting Week 3 loss to the Miami Dolphins has done little to curtail sportsbooks’ affinity for the Buffalo Bills. The Super Bowl favourites sit at playing against the Baltimore Ravens on the road in Week 4.

Indeed, Baltimore’s J.K. Dobbins (ACL) is officially back after playing in Week 3. But the Ravens’ secondary has proven vulnerable giving up a league-leading 353.3 yards per game. To that end, Bills’ QB Josh Allen leads the league in passing yards at 1,014 – something that could be swaying oddsmakers in Buffalo’s favour.

Arizona Cardinals vs. Carolina Panthers

The Arizona Cardinals haven’t led in regulation for the entirety of the NFL season and enter Week 4 as underdogs () for the fourth straight week against the Carolina Panthers.

Granted, the Panthers hasn’t exactly looked spectacular either with Baker Mayfield having the NFL’s worst total quarterback rating. Carolina’s defense, on the other hand, has been timely.

Denver Broncos vs. Las Vegas Raiders

Despite being the only 0-3 team remaining, sportsbooks are favouring the Las Vegas Raiders () for the third consecutive week. The club has lost its opening three contests by a combined 13 points, so they have remained competitive.

Regardless, it won’t be easy again this week. Denver has one of the stingiest defenses in the league, allowing just 12 points (second-lowest) per contest.

New England Patriots vs. Green Bay Packers

One of the biggest spreads of the week belongs to the Packers () vs. Patriots and perhaps that is with good reason.

Consider New England not only dropped its second game of the year in Week 3, but the Pats will almost certainly be without its starting quarterback Mac Jones (ankle sprain) for the foreseeable future.

To complicate matters further, Green Bay – fresh off a gutsy win over Tampa Bay – is playing at home.

Kansas City Chiefs vs. Tampa Bay Buccaneers

Super Bowl LV’s rematch has Kansas City narrowly favoured at over Tampa Bay. Those odds could sway back in the latter team’s favour as Sunday approaches, however.

That’s because Tampa’s wide receiving corp could finally be whole again. Reports indicate Julio Jones (knee) is likely to suit up while Mike Evans is set to return from a one-game suspension.

Los Angeles Rams vs. San Francisco 49ers

With Trey Lance done for the year, Jimmy Garoppolo’s first start of the season had mixed reviews.

“Jimmy G” did some damage by going for 211 passing yards on 18-of-29 attempts. But his team also sputtered, mustering up 10 points for the game and only three points over the last three quarters.

Sportsbooks must still have faith in the veteran QB though.

San Fran is a favourite in the NFL’s primetime MNF matchup.

Jose Colorado is a British Columbia-based writer. He lives in Burnaby and loves sports, anime, writing, business, and the occasional walk on the beach.