NFL Week 2 Betting: Spreads, Totals & Moneylines For All 16 Games

Buffalo Bills quarterback Josh Allen signals during the first half of an NFL football game against the Los Angeles Rams Thursday, Sept. 8, 2022, in Inglewood, Calif. (AP Photo/Mark J. Terrill)

Week 1 gave NFL fans plenty to talk about, and Week 2 is shaping up to be just as exciting. From primetime rivalry matchups between the Green Bay Packers and the Chicago Bears, to potential bounce-back performances from the likes of the reigning Super Bowl Champion Los Angeles Rams, oddsmakers have had their say in the betting markets.

3DownNation breaks down everything you need to know to get the most of the NFL’s 16-game Week 2 slate.

Week 2 NFL odds

Los Angeles Chargers vs. Kansas City Chiefs

A Keenan Allen hamstring injury may be the tipping point causing sportsbooks to favour the Kansas City Chiefs by more than a field over the Los Angeles Chargers in Week’s 2 opening matchup.

For their part, the Chiefs did everything to help their cause in a dominating 44-22 performance in Week 1 – without Tyreek Hill to boot.

New England Patriots vs. Pittsburgh Steelers

The Pittsburgh Steelers’ Week 1 victory came at a steep cost as reigning Defensive Player of the Year TJ Watt went down with a left pectoral injury.

Despite that, and the fact the New England Patriots looked lifeless in Week 1, the Pats are  () on the road.

New York Giants vs. Carolina Panthers

The New York Giants stunned sportsbooks in Week 1 with its 13-point come-from-behind victory. But it took a Herculean effort from Saquon Barkley (164 yards, one TD) to get there.

Carolina’s Baker Mayfield will have to face his road demons (11-20 all-time) in Week 2. For those reasons and more, the G-Men are narrow favourites.

New York Jets vs. Cleveland Browns

With Zach Wilson still recovering from a knee injury, the New York Jets will depend on Joe Flacco for the second consecutive week. The only issue is the quarterback is now 0-8 all-time with the franchise.

That caveat has sportsbooks leaning towards the Browns as favourites in Week 2 – especially after an emotionally charged win against their former quarterback Baker Mayfield in Week 1.

Indianapolis Colts vs. Jacksonville Jaguars

Indianapolis didn’t look good in its Week 1 draw to a lesser Texans team. The Colts have also struggled mightily in Jacksonville – where they happen to be playing in Week 2. In fact, the franchise hasn’t won there since 2014.

Despite that, oddsmakers have the Colts ending the drought this Sunday. Indianapolis is a  favourite.

Miami Dolphins vs. Baltimore Ravens

The Tyreek Hill – Mike McDaniel era hit the ground running as ‘Cheetah’ had eight receptions, 94 yards and 12 targets in Week 1 en route to a convincing 20-7 Week 1 win against the Patriots.

But sportsbooks think Baltimore may have the answer to slow him down. The Ravens are a favourite.

Tampa Bay Buccaneers vs. New Orleans Saints

Neither the Tampa Bay Buccaneers nor the New Orleans Saints looked particularly sharp in Week 1, but for now the former is getting the slight nod as favourites for Week 2.

But with Chris Godwin (hamstring) officially out and Tom Brady’s historical struggles with New Orleans (swept last season), odds could still slightly shift.

Washington Commanders vs. Detroit Lions

Commanders QB Carson Wentz had some flaws in Week 1. But overall, the quarterback was solid for 313 yards and four touchdowns. That’s a good sign as Wentz looks to gain the trust of his new franchise.

Meanwhile, the Lions are hoping their grittiness travels back home after they almost mounted a gutsy comeback in Week 1 against a more talented Eagles squad.

Detroit, playing at home, is the favourite.

Seattle Seahawks vs. San Francisco 49ers

Running back Elijah Mitchell (knee) is out and tight end George Kittle (groin) remains questionable, but the San Francisco 49ers, playing at home, remain favourites for Week 2 against the Seahawks.

Despite Trey Lance’s mediocre performance at quarterback, sportsbooks must be convinced the 49ers’ Week 1 loss was more due to the adverse weather conditions than anything else.

Atlanta Falcons vs. Los Angeles Rams

Despite a humbling 31–10 loss to open the season, the Los Angeles Rams enter as heavy favourites over the Atlanta Falcons in Week 2.

LA – playing at home – should have the fresher legs as the reigning Super Bowl champs played last Thursday night. Atlanta has the worst Super Bowl odds in the entire NFL.

Arizona Cardinals vs. Las Vegas Raiders

Davante Adams (10 catches, 141 yards, one touchdown) was spectacular in his Las Vegas Raiders debut. The only problem? His quarterback, Derek Carr, was equally as bad, throwing three picks and getting sacked five times in the loss.

In Week 2, sportsbooks must be expecting the pair to settle somewhere in the middle as the Raiders sit as favourites.

Houston Texans vs. Denver Broncos

The Texans – holding the second-worst Super Bowl odds in the league – surprised sportsbooks in Week 1 by squeaking out a 20-20 tie against the Colts.

Regardless, sportsbooks aren’t giving that much attention heading into their Week 2 matchup against the favourite Denver Broncos. Russell Wilson – and Denver – were sloppy on the road in their opener (0-4 in red zone, two turnovers).

Perhaps operators think the home field advantage will settle them down.

Cincinnati Bengals vs. Dallas Cowboys

Life without Dak Prescott officially begins in Week 2. The Cowboys’ star quarterback went down in Week 1 with a thumb injury and will be sidelined for the foreseeable future.

Cooper Rush takes his place spot but sportsbooks don’t have much faith in the backup. Cincy – despite coming off a Week 1 loss – is heavily favoured ().

Chicago Bears vs. Green Bay Packers

Aaron Rodgers’ young receiving corp was woeful in Week 1, combining for 11 catches, 95 yards, no touchdowns and multiple drops.

And help in the form of Allen Lazard (ankle) likely isn’t on the way either. Reports indicate the wide receiver is probable to miss his second straight week. Regardless, sportsbooks think the Packers () get their act together at Lambeau Field.

Tennessee Titans vs. Buffalo Bills

The Bills emphatically reminded the football world why they are this year’s consensus Super Bowl favourites () in Week 1 by walloping the Rams 31-10 at SoFi Stadium.

On the other hand, Tennessee immediately felt the absence of Harold Landry (ACL) in its 21-20 Week 1 loss. Giants running back Saquon Barkley got loose early and often.

All things considered; the Bills as favourites seems reasonable.

Minnesota Vikings vs. Philadelphia Eagles

Confidence is likely running high in Minnesota after its resounding 23-7 win against the Green Bay Packers in Week 1. The Vikings’ new coaching staff unleashed wide receiver Justin Jefferson for 184 yards and two touchdowns – something to keep an eye on against an Eagles defence that was torched in the second half against Detroit last week.

Despite that, Philadelphia remains a favourite heading in.

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Jose Colorado is a British Columbia-based writer. He lives in Burnaby and loves sports, anime, writing, business, and the occasional walk on the beach.