The players have voted and chosen the Canadian Football League Players’ Association all-star team for the 2021 season. CFLPA all-star nominations are considered to be highly prestigious as they are voted on by peers — for the players and by the players. The 2021 vote was made available to all current CFLPA members on each team. There were more than 300 ballots cast and only players who had played nine or more games during this shortened season were eligible to be on a ballot. Players could not vote for any player or coach who is a member of their own team and could only vote for other players they most closely study and compete directly against week in and week out. For example, receivers and slot backs were voted for by defensive backs. In addition, all CFLPA members voted for one 2021 all-star head coach and one special teams player.
| POSITION | PLAYER | TEAM |
| QB | Zach Collaros | Winnipeg |
| FB | Nikola Kalinic | Hamilton |
| RB | William Stanback | Montreal |
| SB | Bryan Burnham | BC |
| SB | Nic Demski | Winnipeg |
| REC | Kenneth Lawler | Winnipeg |
| REC | Lucky Whitehead | BC |
| C | Michael Couture | Winnipeg |
| OG | Sukh Chungh | BC |
| OG | Matthew O’Donnell | Edmonton |
| OT | Stanley Bryant | Winnipeg |
| OT | Jermarcus Hardrick | Winnipeg |
| DE | Willie Jefferson | Winnipeg |
| DE | Jackson Jeffcoat | Winnipeg |
| DT | Almondo Sewell | Montreal |
| DT | Micah Johnson | Saskatchewan |
| WLB | Jameer Thurman | Calgary |
| MLB | Adam Bighill | Winnipeg |
| SLB | Patrick Levels | Montreal |
| HB | Ciante Evans | Hamilton |
| HB | Cariel Brooks | Hamilton |
| CB | DeAundre Alford | Winnipeg |
| CB | Jonathan Moxey | Calgary |
| S | Brandon Alexander | Winnipeg |
| K | Rene Paredes | Calgary |
| P | Richie Leone | Ottawa |
| LS | Jorgen Hus | Saskatchewan |
| ST | DeVonte Dedmon | Ottawa |
| HC | Mike O’Shea | Winnipeg |
